Nuclear Receptors as drug targets

Nuclear Receptors are of major importance for the body's homeostasis, as they integrate different intra- and extracellular signalling to initiate and regulate gene expression programs. This key role in a wide variety of signalling pathways qualifies them as important pharmacological targets.

Nuclear Receptor modulating drugs account for about 20% revenues of the total ethical drug market, applied in different indications, such as Hormone Replacement Therapy, Women's Health, Inflammation, Diabetes, Cancer and Dermatology.

As next generation Nuclear Receptor drugs, patients and doctors need selective and partially modulating Nuclear Receptor compounds with reduced side effects to reach better therapeutic ratios.

More information on the biological basis of selective Nuclear Receptor modulation:

- The SNuRM® Approach
- SNuRM® Profiling