Y2H - NRs have their specific cofactor profile

Cofactor profiles are receptor specific, however can be remarkably similar (as for the activated estrogen receptor and the constitutive estrogen receptor related receptor).

 

Estrogen Receptor (ER) + 17β-estradiol

Estrogen-related Receptor α (ERRα) no ligand

Androgen Receptor (AR) + testosterone

Vitamin D Receptor (VDR) + 1,25(OH)VitD3