Publications & Posters
RORyt
Publications
Identification and biological evaluation of thiazole-based inverse agonists of RORγt.
Gege C, Cummings MD, Albers M, Kinzel O, Kleymann G, Schlüter T, Steeneck C, Nelen MI, Milligan C, Spurlino J, Xue X, Leonard K, Edwards JP, Fourie A, Goldberg SD, Hoffmann T.
Bioorg Med Chem Lett. 2018 May 15;28(9):1446-1455. Epub 2018 Apr 3.
Xue X, Soroosh P, De Leon-Tabaldo A, Luna-Roman R, Sablad M, Rozenkrants N, Yu J, Castro G, Banie H, Fung-Leung WP, Santamaria-Babi L, Schlüter T, Albers M, Leonard K, Budelsky AL, Fourie AM.
Sci Rep. 2016 Dec 1;6:37977.
Posters
Gege C, Schlüter T, Hoffmann T.
Bioorg Med Chem Lett. 2014 Nov 15;24(22):5265-7. Epub 2014 Sep 28.
FXR
Publications
Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice.
de Boer JF, Schonewille M, Boesjes M, Wolters H, Bloks VW, Bos T, van Dijk TH, Jurdzinski A, Boverhof R, Wolters JC, Kuivenhoven JA, van Deursen JM, Oude Elferink RPJ, Moschetta A, Kremoser C, Verkade HJ, Kuipers F, Groen AK.
Gastroenterology. 2017 Apr;152(5):1126-1138. Epub 2017 Jan 5.
Schwabl P, Hambruch E, Seeland BA, Hayden H, Wagner M, Garnys L, Strobel B, Schubert TL, Riedl F, Mitteregger D, Burnet M, Starlinger P, Oberhuber G, Deuschle U, Rohr-Udilova N, Podesser BK, Peck-Radosavljevic M, Reiberger T, Kremoser C, Trauner M.
J Hepatol. 2017 Apr;66(4):724-733. Epub 2016 Dec 18.
Kinzel O, Steeneck C, Schlüter T, Schulz A, Gege C, Hahn U, Hambruch E, Hornberger M, Spalwisz A, Frick K, Perovic-Ottstadt S, Deuschle U, Burnet M, Kremoser C.
Bioorg Med Chem Lett. 2016 Aug 1;26(15):3746-53. Epub 2016 May 24.
Deuschle U, Birkel M, Hambruch E, Hornberger M, Kinzel O, Perovic-Ottstadt S, Schulz A, Hahn U, Burnet M, Kremoser C.
Int J Cancer. 2015 Jun 1;136(11):2693-704. Epub 2014 Nov 13.
Gege C, Kinzel O, Steeneck C, Schulz A, Kremoser C.
Curr Top Med Chem. 2014;14(19):2143-58. Review.
Posters
EASL The International Liver Congress 2019, April 10-14, Vienna, Austria
European Association for the Study of the Liver: “The International Liver Congress™ 2016”, April 13-17, 2016, Barcelona, Spain
FXR controls the tumor suppressor Histidine Rich Glycoprotein (HRG).
Falk Symposium 194: “XXIII International Bile. Acid Meeting: Bile Acids as Signal Integrators and. Metabolic Modulators”, October 89, 2014 Freiburg, Germany
FXR agonist Px-102 improves hepatic steatosis in NAFLD mouse models.
The Asian Pacific Association for the Study of the Liver: “APASL Liver week”, Juni 6-10, 2013 Singapore, Malysia
DKFZ-ZMBH Alliance Forum: “Metabolism 2012 From Signaling to Disease”, November 15-16, 2012 Heidelberg, Germany
The 9th JSH Single Topic Conference :”NASH 2010″ November 18-19, 2010 Tokyo, Japan
LXR
Publications
Albers M, Blume B, Schlueter T, Wright MB,
Kober I, Kremoser C, Deuschle U, Koegl M.
J Biol Chem. 2006 Feb 24;281(8):4920-30. Epub 2005 Dec 13.
Posters
Liver X Receptor (LXR) inverse agonist PX665 for NAFLD/NASH
Discovery on Target 2019, September 16-19, Boston, MA, USA
American Association for the Study of the Liver Diseases: “The Liver Meeting™ 2018”, November 9-13, 2018 San Francisco, USA
European Association for the Study of the Liver: “The International Liver Congress™ 2018”, April 11-15, 2018, Paris, France
NASH tag conference 2017, January 5-7, Utah, USA
American Association for the Study of the Liver Diseases: “The Liver Meeting™ 2016”, November 11-15, 2016 Boston, USA
AHR / IDO
Publications
Steeneck C, Kinzel O, Anderhub S, Hornberger M, Pinto S, Morschhaeuser B, Braun F, Kleymann G, Hoffmann T.
ACS Med Chem Lett. 2020 Jan 27;11(2):179-187. eCollection 2020 Feb 13.
Posters
Discovery of Small Molecule Aryl Hydrocarbon Receptor(AhR) Antagonists for Cancer Immunotherapy
Discovery on Target 2019, September 16-19, Boston, MA, USA
Targeting the IDO1-Kynurenine-AhR pathway for cancer immunotherapy
AACR Annual Meeting 2019, March 29 – Apr 3, 2019, Atlanta, Georgia, USA
Identification and Profiling of PX-D26116, a potent Hydroxyamidine-based IDO1 Inhibitor.
CIMT 2018 Annual Meeting, May 15-17, 2018, Mainz, Germany
CIMT 2018 Annual Meeting, May 15-17, 2018, Mainz, Germany
Cancer Metabolism
Posters
AACR Annual Meeting 2019, March 29 – Apr 3, 2019, Atlanta, Georgia, USA
Basic research
Publications
Kremoser C, Albers M, Burrris TP, Deusche U, Koegl M.
Drug Discov Today. 2007 Oct;12(19-20):860-9. Epub 2007 Sep 19.
Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
Albers M, Kranz H, Kober I, Kaiser C, Klink M, Suckow J, Kern R, Koegl M.
Mol Cell Proteomics. 2005 Feb;4(2):205-13. Epub 2004 Dec 15.